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University of Michigan Summary: A carbon-nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before.

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The engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.

Doctors routinely use focused sound waves to blast apart kidney stones and prostate tumors, for example.

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The tools work primarily by focusing sound waves tightly enough to generate heat, says Jay Guo, a professor of electrical engineering and computer science, mechanical engineering, and macromolecular science and engineering. Guo is a co-author of a paper on the new technique published in the current issue of Nature's journal Scientific Reports.

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The beams that today's technology produces can be unwieldy, says Hyoung Won Baac, a research fellow at Harvard Medical School who worked on this project as a doctoral student in Guo's lab.

Therefore, it can be difficult to treat tissue objects in a high-precision manner, for targeting delicate vasculature, thin tissue layer and cellular texture.

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We can enhance the focal accuracy fold. Their beam can blast and cut with pressure, rather than heat.

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Guo speculates that it might be able to operate painlessly because its beam is so finely focused it could avoid nerve fibers. The device hasn't been tested in animals or humans yet, though.

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And it is so tightly focused, you can disrupt individual cells. The general technique has been around since Thomas Edison's time. It has advanced over the centuries, but for medical applications today, the process doesn't normally generate a sound signal strong enough to be useful.

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The U-M researchers' system is unique because it performs three functions: it converts the light to sound, focuses it to a tiny spot and amplifies the sound waves. To achieve the amplification, the researchers coated their lens with a layer of carbon nanotubes and a layer of a rubbery material called polydimethylsiloxane.

The carbon nanotube layer absorbs the light and generates heat from it.

Then the rubbery layer, which expands when exposed to heat, drastically boosts the signal by the rapid thermal expansion. The resulting sound waves are prostate et constipation, times higher frequency than humans can hear.

They work in tissues by creating shockwaves and microbubbles that exert pressure toward the target, which Guo envisions could be tiny cancerous tumors, artery-clogging plaques or single cells to deliver drugs.

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The technique might also have applications in cosmetic surgery. In experiments, the researchers demonstrated micro ultrasonic surgery, accurately detaching a single ovarian cancer cell and blasting a hole less than micrometers in an artificial kidney stone in less than a prostate et constipation.

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Jay Guo. Scientific Reports, ; 2 DOI: