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Asap prostate

In vivo evaluation of Fe3O4 nanoparticles Roxana Cristina Popescu, Ecaterina Andronescu, Alexandru Mihai Grumezescu Our review summarizes the latest approaches regarding in vivo asap prostate evaluation of magnetite nanoparticle-based systems.

The paper follows the applications of Fe3O4 nanoparticles in cancer diagnosis and treatment, by means of nanoparticle-mediated magnetic hyperthermia, respectively by targeted delivery of chemotherapeutics. The long-term biodistribution in relevant organisms is also discussed, due to the need of knowing the exact course of magnetite nanoparticles after the fulfillment of their function.

Several commercial Fe3O4 systems used as contrast agents for medical imaging and cancer treatment by hyperthermia are briefly presented in the last section.

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Molecular diagnosis of autoimmune skin diseases Roxana Chiorean, Michael Mahler, Cassian Sitaru A wide range of skin diseases are associated with autoimmune responses against skin-specific or ubiquitous antigens. The presence of tissue-bound and circulating autoantibodies does not only bear relevance for disease pathogenesis, but also allows developing robust diagnostic tools and molecular therapeutic approaches.

Thus, various immunofluorescence methods, as well as molecular immunoassays, including enzyme-linked immunosorbent assay and immunoblotting, belong to the modern diagnostic algorithms for these disorders. This review article describes the immunopathological asap prostate of autoimmune skin diseases and the molecular assays currently available for their diagnosis and monitoring.

Advanced techniques show that these microparticles have their clinical implications in the prevention and prediction in pathology and have potential in the discovery of novel therapeutic approaches to metabolic diseases such as diabetes, cardiovascular, autoimmune diseases and cancer. Hepatic asap prostate background in chronic hepatitis B and C - significance of similarities and differences Eugenia Morosan, Maria Sultana Mihailovici, Simona Eliza Giusca, Elena Cojocaru, Elena-Roxana Avadanei, Irina-Draga Caruntu, Sergiu Teleman The aim of our study was to investigate comparatively the steatotic background in viral chronic hepatitis B, C and mixed types, in correlation with the severity degree of specific liver lesions.

The study group consisted of liver biopsy specimens, etiologically asap prostate as hepatitis C - The histopathological assessment focused on the steatotic lesions associated with inflammation and fibrosis. The cases were classified according to necrosis and giardioza si prostatita activity score between and fibrosis score between Our data indicates significant association of steatotic lesions in hepatitis C In mixed hepatitis B asap prostate prostate C, steatotic lesions are more frequent Steatosis was present in all cases with chronic hepatitis C and associated toxicity.

These observations confirm the important aggressiveness of hepatitis C virus as opposed to hepatitis B and D virus. The analysis of the pattern of steatosis in correlation with necrosis and inflammatory activity and fibrosis, respectively, lead to the identification of certain specific elements.

Prevenirea prostostatitei Selzinc

Thus, for all types of hepatitis, steatosis is associated predominantly with moderate severity score and progressive expansion of fibrosis score The presence of steatosis does not define hepatic lesions with severe inflammation score nor those with extended fibrosis score 4. The type of steatosis asap prostate is mostly macrovesicular, the transformation into lipid cysts being uncommon.

Based on the scoring systems applied in the evaluation of the entire investigated study group, we believe that a possible inclusion of a quantifiable criterion for steatosis could be beneficial in order to complete the characterization of the severity of the lesions, from the point of view of the potential for future evolution, reversible or irreversible.

The immunohistochemical investigations of cadherin switch during epithelial-mesenchymal transition of tongue squamous cell carcinoma Mihai-Catalin Afrem, Claudiu Margaritescu, Monica Mihaela Craitoiu, Mirela Ciuca, Calin-Gabriel Sarla, Ovidiu Simion Cotoi Oral cancer was ranked as the sixth worldwide most common cancer, but recent studies noticed an overall downward trend in its incidence.

However, for tumors localized on the tongue, the incidence seems to increase. The malignant transformation of asap prostate carcinomas is associated with loss of epithelial differentiation and gain of a mesenchymal phenotype, a process known as epithelial-mesenchymal transition EMT which for oral squamous cell carcinomas OSCC could be a predictor and a prognostic factor.

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E-cadherin reactivity was recorded in all the investigated cases, the pattern of expression being both membranous and cytoplasmic, with the membrane pattern decreasing simultaneously with the decrease of the differentiation degree and with the increase of invasion phenotype, while the cytoplasmic pattern had an opposite behavior.

Tumor parenchyma reactivity for vimentin was noticed in Asap prostate reactivity was restricted to only In conclusion, in tongue squamous cell carcinomas at the invasion front the E-cadherin reactivity decreases while vimentin expression increases, with a cytoplasmic N-cadherin reactivity in a few of the observed cases.

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This EMT phenotype was correlated with the decrease of differentiation degree, with the increase of the type of invasion pattern and with increasing disease stages and thus asap prostate EMT markers could be used for prognostic stratification of such patients. Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and correlation with prognosis Aleodor A. Siegal Merkel cell carcinoma MCC is a rare, but highly aggressive primary cutaneous malignancy, showing neuroendocrine differentiation.

Ina novel member of the polyomavirus family, named Merkel cell polyomavirus MCPyV was identified in the genome of MCC tumors raising the possibility of an involvement in its pathogenesis. Due to the rarity of this tumor and current pathology practices, the most readily available asap prostate is archival formalin-fixed, paraffin-embedded FFPE material. Representative FFPE specimens from 18 tumors belonging to 14 patients with a diagnosis of MCC spanning the period from to were retrieved.

There was no significant correlation between the presence of the virus and the stage at presentation; however, tumors in the head and neck area had a lower frequency of viral positivity compared to those arising in the extremities suggesting a MCPyV-independent oncogenetic pathway perhaps, dependent on UV exposure, in a subset of these cases. Corresponding author: Aleodor A. Prognostic factors in anterior skull base meningiomas Liviu Marian Ciocan, Leon Danaila, Diana Eugenia Stanculescu, Simona Daniela Neamtu, Garofita Olivia Mateescu, Liliana Stanca Aim: Histopathological and immunohistochemical study of prognostic factors in anterior skull base meningiomas in order to determine the post-operative management.

Materials and Methods: The studied material consisted in resection specimens from 65 patients with anterior skull base meningiomas hospitalized asap prostate Clinic of Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania, and diagnosed in the Department of Pathology of the same Institute, between and The biological material was processed by standard histological technique with Hematoxylin and Eosin staining which allowed the classification of tumors according to WHO system and the assessment of the morphological parameters of known prognostic value.

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Subsequently, the tumor fragments were submitted to immunohistochemistry to evaluate the proliferative activity Ki labeling index and progesterone hormone receptor PR status. Results: Both mitotic activity and infiltrative and invasive tumor growth the latter found in Ki labeling index ranged between 1.

The immunonegative PR tumors were represented by In contrast to PR, Ki expression was statistically correlated with tumor grade. The comparison between the expression of Ki and PR revealed an inverse relationship between the level of PR expression and the asap prostate activity intensity.

Asap prostate We found that PR expression decreases as the biological behavior of tumor becomes more aggressive; it may be related with an increased risk of recurrence, making the postoperative surveillance more rigorous in these patients. Corpora amylacea in the brain form highly branched three-dimensional lattices Ionica Pirici, Claudiu Margaritescu, Laurentiu Mogoanta, Florin Petrescu, Cristiana Eugenia Simionescu, Elena Silvia Popescu, Serghei Cecoltan, Daniel Pirici Corpora amylacea CA are glycoprotein-based depositions that accumulate in the normal aging brain or consecutively to different neuro-degenerative diseases.

Although controversies still exists in what it regards their origins and functions, their morphology is described simply as round basophilic entities based on bi-dimensional observations.

Înțelesul "acinar" în dicționarul Engleză

The aim of the present study was to evaluate the three-dimensional morphology of these bodies in usturime la urinare barbati cauze brain in normal aging.

We utilized here brain tissue from six aged patients, and performed an in-depth stereological analysis of CAs based on series of thin serial sections, and 50 micro-m-thick sections. Three-dimensional renderings have been obtained after aligning the serial sections, while high-resolution z-stacks have resulted after deconvolution on the thick sections.

There was a direct correlation between the diameter of the vessels and the number of associated CAs. Astrocyte GFAP and aquaporin 4 signals surrounded CAs, but without any colocalization with the ubiquitin areas, while perivascular CAs were sometimes enclosed in pockets of the basement membranes. In conclusion, as far as we know, this is the first asap prostate to describe the three-dimensional branching complexity of corpora amylacea in the brain. Bone marrow edema - premonitory sign in malignant hemopathies or nonspecific change?

Histologically, BME is characterized by accumulation of extracellular eosinophilic fluid.

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Magnetic Resonance Imaging MRI is the only method that highlights the presence of BME caused by various diseases, including the one associated with hematological malignancies. Out of the 30 patients with BME, 24 were known asap prostate have a malignant hematological disease multiple myeloma, leukemia, lymphoma ; for the remaining subjects, imagistic findings and other laboratory investigations led to multiple myeloma diagnosis.

Of the 30 patients, six showed characteristic lesions of the underlying disease as well as BME; four patients had only BME. BM is a structure that is commonly investigated using MRI scans, regardless of the examined bone segment.

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T1-weighted images and T2-weighted with fat suppression are essential for BME evaluation. Moreover, MRI allows monitoring disease progression and treatment response in patients with malignant hemopathies. Biopsying parapsoriasis: quo vadis?

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Are morphological stains enough or are ancillary tests needed? Flavia Baderca, Elena Chiticariu, Michael Baudis, Caius Solovan Background: Parapsoriasis represents a group of cutaneous disorders that shows variable clinical aspects somehow resembling to psoriasis, how is reflecting by its name. It was first named by Brocq, inas an entity with three components: pityriasis lichenoides, small plaque parapsoriasis and large plaque parapsoriasis.

Nowadays, under the name of parapsoriasis are included only the last two categories, that are considered disorders characterized by the presence of a mononuclear infiltrate in the dermis, composed of T-cells. Until now, there were not established pathognomonic histopathological features to diagnose parapsoriasis. Aim: The aim of the study was to investigate the epidemiological and morphological data of parapsoriasis cases diagnosed at Emergency City Hospital, Timisoara, Romania for a period of 12 years.

Materials and Methods: The study had two parts; one was retrospective and another one prospective. For the retrospective part, we searched patient files recorded in our Pathology Service for a period of 11 years, from January to December Tratamentul prostatitei tver slides were searched asap prostate the archive and re-read by two individual pathologists. For prospective part of the study, we reviewed histological slides read between January and June After inspection of the recorded files, the pathologists noted, were available, the localization and number of the lesions, together with symptoms.

The biopsied specimens were initially processed with routine histological technique, the archive slides being stained with Hematoxylin and Eosin. While reading the slides, the pathologists paid attention to the architecture of the epidermis, the presence of epidermotropism and interface dermatitis, type of the dermal infiltrate and its distributions.

Conclusions: In the present study, we emphasized the histopathological aspects of parapsoriasis in order to create a basic line that could help in the establishment of a uniformly accepted definition of parapsoriasis on histopathological grounds. Materials and Methods: The study was conducted on untreated patients with permanent dentition, aged 16 to 25 years, which were divided into three groups, according to Angle s classification of occlusion. The measurements of asap prostate dento-alveolar intercanine, interpremolar and intermolar widths were made on virtual study models, scanned using an optical 3D scanner.

The anatomo-radiological study of unusual extrasinusal pneumatizations: asap prostate and supreme turbinate, crista galli process, uncinate process Mihail Dan Cobzeanu, Vasilica Baldea, Mircea Catalin Baldea, Patricia Sonia Vonica, Bogdan Mihail Cobzeanu Introduction: One of the aspects that have an influence on rhinosinusal endoscopic surgery is extrasinusal pneumatization, which can also affect less common structures at this level.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

The pneumatization of the superior and supreme turbinates, uncinate process and crista galli are perfect examples of this asap prostate. The diagnosis is made only through imaging methods. Materials and Methods: This is a retrospective anatomo-radiological study analyzing CT scans of the facial sinuses performed over a three years period.

All patients were symptomatic and the CT scans were performed to assess the cases prior to surgery. Ninety-seven patients were females and males, aged between 18 and 91 years. Results: The prevalence of pneumatization and the prevalence of the different pneumatization types superior and supreme turbinate, uncinate process and crista galli were determined.

Conclusions: The pneumatization of the supreme turbinate Pneumatization of the crista galli process was recorded in The purpose of this study was to investigate whether aortic diameters measured on tissue samples obtained during autopsy from subjects that died of cardiovascular disease were bigger when compared to those from subjects deceased from other cause than cardiovascular disease. Morphological measurements were completed on aortic specimens obtained from four different sites, namely ascending aorta, aortic arch, distal thoracic aorta and abdominal aorta.

Aorta showed the tendency to decrease in diameter from asap prostate aorta to abdominal aorta, the latter presenting with the smallest diameter.

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All studied aortic diameters were found to be larger in the cardiovascular population p Corresponding author: Iancu Emil Plesea, Professor, Asap prostate, PhD; e-mail: pie yahoo. A morphometric study of multiple renal arteries in Greek population and a systematic review Konstantinos Natsis, George Paraskevas, Eleni Panagouli, Athanasios Tsaraklis, Evangelos Lolis, Maria Piagkou, Dionysios Venieratos The aim of the study was to determine the distribution patterns of multiple renal arteries, evaluate how they are affected by gender and bilateral asymmetry and proceed on a systematic review.

Two hundred and six kidneys from Greek cadavers 53 males and 50 females were investigated. The number and pattern of multiple renal arteries were determined according to side, gender and level of origin.

The distances between the main renal and first multiple renal arteries were also measured. Multiple renal arteries were present in In Etiopathogenetic, clinical and histopathological aspects regarding the involvement of dental focal infection in premature births with fetal hypotrophy Gabriel-Radu Rica, Claudia Paula Badi, Ana-Maria Rica, Carmen-Mirela Sirbu, Nicolae Rica The study conducted on a total of preterm births, of which hypotrophic fetuses births between within the Maternal Clinics of Craiova, Romaniastudied the involvement of dental inflammatory infections asap prostate the chorioamnionitis onset.

The possibility of transferring germs, toxins and degraded materials into the blood flow, and them entering the chorioamniotic structures is quite a common issue. Subclinically often evolving chorioamniotic membrane and its existence is clearly established after birth by histopathological and bacteriological examinations, being partially responsible for the growth delay of the conception product. Our study revealed this fact, by using clinical examinations, ultrasound exams, bacteriological determinations of the amniotic fluid and the placenta, alongside the histopathological examinations.

The chorioamnionitis inflammatory process is responsible for premature birth, through a high synthesis of interleukins IL and prostaglandins, causing uterine contractions. Our IL-6 dosage determinations show its growth that can be considered a prediction marker for preterm birth. Immunohistochemical analysis in the diagnosis of uterine myometrial smooth muscle tumors Anca Daniela Stanescu, Elena Nistor, Maria Sajin, Alex Emilian Stepan Uterine myometrial smooth muscle tumors sometimes raise concerns related to their histopathological typing, and that especially for benign entities asap prostate areas of atypia.

In this study, we analyzed a group of myometrial smooth muscle tumors in what it regards their differential diagnosis utilizing a panel of antibodies consisting of alpha-SMA, Ki, p16, p53, PR and bcl The study included a total of 16 cases of cellular leiomyomas, five cases of atypical leiomyomas and six of leiomyosarcomas, which were all analyzed for durere persistentă cu prostatita, risk factors, mitotic activity, cellular atypia and tumor staging.

In cases of cellular leiomyomas, the immunophenotype was characterized by high expression of PR and bcl-2 and low expression of p53 and Ki For atypical leiomyomas, PR, bcl-2 and p53 expression levels were highly compared with low levels of p16 and Ki Leiomyosarcomas immunophenotype was characterized by high expression values of Ki, p16 and p53, and decreased levels of PR and bcl Asap prostate study indicated specific immunophenotypes among asap prostate uterine myometrial smooth muscle tumors analyzed.

Asap prostate antibody panel used here might be a useful for the complementary histopathological asap prostate of myometrial leiomyomas and leiomyosarcomas.

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Matrix prostatita de instalare -7, -8, asap prostate and in gingival tissue of patients with type 1 diabetes and periodontitis Petra Surlin, Bogdan Oprea, Sorina Mihaela Solomon, Simona-Georgiana Popa, Maria Mota, Garofita Olivia Mateescu, Anne-Marie Rauten, Dora-Maria Popescu, Lucian-Paul Dragomir, Ileana Puiu, Maria Bogdan, Mihai Raul Popescu There is scientific data to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, asap prostate periodontal inflammation negatively affecting the diabetic status.

Our study aims to investigate the expression of MMP-7, -8, -9 and in the gingiva of the young patients with aggressive periodontitis AP and type 1 diabetes mellitus T1D. The MMP-8 immunostaining was positive in all cases. The MMP-9 immunoreaction was present in all the structures of the gingival mucosa with different intensity, being frequently present surrounding the blood vessels of the chorion.

In most of the patients, reaction to Asap prostate was intense, localized at the level of the cells in the superficial chorion and very rarely at the level of some dispersed cells in the connective vascular islands.

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The expression of MMP-7, -8, -9 and in the gingiva of the young patients with aggressive periodontitis and T1D was positive in all studied cases supporting the hypothesis that both are inflammatory diseases with common pathogenic mechanisms involving inflammatory mediators cum se face asap prostate de prostatita may be possible biomarkers of disease status.

Cytoarchitecture of steroid dependent target tissues after testosterone administration compared to nandrolone decanoate in castrated rats in the aim of Hershberger bio test Romeo Teodor Cristina, Flavia Hanganu, Diana Brezovan, Eugenia Dumitrescu, Florin Muselin, Viorica Chiurciu, Adrian Constantin Stancu, Marius Cristian Pentea, Andrei Gheorghe Asap prostate Motoc The objective was the cytoarchitecture evaluation of known steroid dependent target tissues after administering of testosterone, compared to action of its more active ester, nortestosterone nandrolone decanoate in castrated rat males in the aim of Hershberger bio test.

Study was performed on 30 castrated male Wistar rats, aged between 35 and 39 days, in peripubertal period, divided into five groups.