There is a discrepancy in the Gleason score given on the initial biopsy and prostatectomy specimen, respectively, that affects both patients who can benefit from active surveillance and those who cannot benefit from curative surgical treatment, and for whom therapeutic alternatives must be established.
Inclusion Criteria: - Adult men over 40 years old with prostate cancer qualified for radical prostatectomy - Control group formed from 20 healthy men aged years old without any urological conditions and no lower urinary tract symptoms LUTS. Exclusion Criteria: - Neoadjuvant any time before or adjuvant radiotherapy or brachytherapy within the follow-up period of 12 months.
In this context, our study aimed at analyzing the diagnostic concordance between biopsies and subsequent prostatectomies, in order to establish the accuracy of prostate biopsy in radical prostatectomy final Gleason score of the prostatectomy specimens. Material and methods: We analyzed 79 cases of PADK, initially diagnosed by prostate biopsy and subsequently treated by radical prostatectomy.
The accuracy degree of the tumoral grading system assigned to the prostate biopsy, compared with the radical prostatectomy, was assessed by calculation of the Radical prostatectomy kappa concordance coefficient and calculation of sensitivity, specificity, positive prognostic value and negative prognostic value. Results: 37 cases In prostate biopsies, 32 cases The lowest agreement rate was observed for Gleason score 5, where no case showed a similar score for biopsy and prostatectomy.
Statistical analysis indicated a kappa coefficient of 0.
The agreement on ISUP prognostic grade groups between prostate biopsy and radical prostatectomy indicated a slight increase in radical prostatectomy coefficient Conclusions: Our results demonstrate an increase in the predictive accuracy of prostate biopsy, as a result of the application of prognostic grade group system, which ensure the decrease of overestimating tendency of the old scoring radical prostatectomy, ultimately leading to a preliminary characterization of potential lesions in prostatectomy specimens and a more effective treatment stratification of patients.
Author Biographies A. Lyon: International Agency for Research on Cancer, A contemporary prostate cancer grading system: A vali-dated alternative to the Radical prostatectomy score. Eur Urol ; 69 3 : Gleason DF. Classification of prostatic carcinomas.
Cancer Chemother Rep ; 50 3 Prediction of prognosis for prostatic adenocarcinoma by combined histo-logical grading and clinical staging. J Urol ; 1 : Histological grading and staging of prostatic carcinoma. Philadephia: Lea and Feibiger, Histologic grading radical prostatectomy prostate cancer: a perspective.
Hum Pathol ; 23 3 : Am J Surg Pathol ; 29 9 : J Clin Oncol ; 27 21 : J Urol ; 6 : — Epstein JI. An update of the Gleason grading system.
Helpap B, Egevad L. Modified Gleason grading. An updated review.
Radical prostatectomy Histopathol ; 24 5 : Radical prostatectomy Urol ; 58 3 : Arch Pathol Lab Med ; 4 : The impact of the Interna-tional Society of Urological Pathology Gleason grading consensus on active surveillance for prostate cancer. Cent European J Urol ; 70 4 : Upgrading and upstaging in prostate cancer: From prostate biopsy to radical prostatectomy. Mol Clin Oncol ; 2 6 : J Clin Oncol ; 34 18 : Front Med Lausanne ; 4: Prostate cancer grading: a decade after the modified system.
Что-то подсказывало Сьюзан, что они близки к разгадке. - Мы можем это сделать! - сказала она, стараясь взять ситуацию под контроль. - Из всех различий между ураном и плутонием наверняка есть такое, что выражается простым числом. Это наша главная цель.
Mod Pathol ; 31 S1 : SS Grignon DJ. Prostate cancer reporting and radical prostatectomy needle biopsy and radical prostatectomy specimens. Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites.
Mod Pathol ; 18 2 : Evaluation of concordance of Gleason score between prostatectomy and biopsies that show more than two different Gleason scores in positive cores. Urology ; 67 1 : Multiple prostate cancer cores with different Gleason grades submitted in the same specimen container without specific site designation: should each core be assigned an individual Gleason score?
Hum Pathol ; 40 4 :
Source: Acta Medica Transilvanica. The purpose of this study is represented by the clinical evaluation of the effectiveness of open radical retropubic prostatectomy with bilateral ilio-obturator lymph node dissection in patients with prostate cancer. We studied a group of patients who underwent open radical retropubic prostatectomy radical prostatectomy prostate cancer in localized stage between January - February The average age of patients was Preoperative PSA level was between 2.